Investigating the role of Quaking in dendritic cells

Abstract Dendritic cells (DCs) are essential players in the anti-tumor immunity, which often found dysfunctional tumor microenvironment. Impairing DC antigen processing and presentation, subverts T cell priming, is one of primary mechanisms by escape immune surveillance. However, cellular factors regulating presentation DCs how render DCs’ priming capacity not fully understood. We revealed a potential regulatory role an RNA-binding protein, Quaking (QKI), DCs. Consistent with our previous studies neural stem microglia, we QKI could regulate phagocytosis promoting formation phagosome endosomes QKI-deficient showed reduced CD8 +T vitro. Furthermore, knocking out accelerated growth vivo. Together, these suggest pivotal function further enhance understanding regulated In addition, to be downregulated tumor-infiltrating DCs, as compared normal tissues. How impair suppressing expression currently under investigation. This will reveal new mechanism modulate immunity can provide strategies target for improving cancer immunotherapy.